To answer the question of “can you take Xanax and Prozac together,” it may be fine, and there aren’t necessarily any significant risks known with using the two together. With that being said, you should always only follow the instructions of your doctor. How to use Ambien. Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking zolpidem and each time you get a refill. Is it safe to take ritalin and prozac together? Trish McLemore, Associates History and Philosophy & I Have Personal Experience with Many Mental Health Meds.. Sleepless, Yes this is a fairly common combination check with your doctor and see they also sometimes take just the Trazodone every night and the doctor may have you add the Ambien to take with it 3 nights a week just see what your doctor wants you to do. Prozac (fluoxetine) is one of the most widely prescribed antidepressants in the world. Ambein CR (extended release zolpiderm) is a prescription sleep aid medication. PROZAC + ABILIFY is not alright to take unless the dosage of both is halved (and PROZAC stopped 3 or 5 days before : very long half-life). Drug interactions in medicine is a complex affair. As a rule don’t add any drug to any other. Summary. Drug interactions are reported among people who take Prozac and Ambien together. This study is created by eHealthMe based on reports of 3,073 people who take Prozac and Ambien from FDA, and is updated regularly. Can you take ambien with zoloft. Common Questions and Answers about Can you take ambien with zoloft. ambien. Zoloft can make some people feel like they are in a daze half the time. Your really need to be careful going to two different docs like that as that can cause troubles regarding meds. You need to make sure at least one doc is getting all the doc reports from the other docs. Read More. Lunesta, Ambien, Ambien CR, Remeron, etc. The best thing I have found, and it's non addictive/no side effects , to take a benedryl 1/2 hr before I go to bed. Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together.